apalutamide will reduce the level or effect of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a robust CYP3A4 inducer, with medicine which have been CYP3A4 substrates can lead to reduced exposure to those drugs.Co-codamol is a mix analgesic that is made up